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TCDB: the Transporter Classification Database for membrane transport protein analyses and information
Division of Biological Sciences, University of California at San Diego La Jolla, CA 92093-0116, USA
*To whom correspondence should be addressed. Tel. +1 858 534 4084; Fax: +1 858 534 7108; Email: msaier{at}ucsd.edu
Received April 8, 2005. Revised July 7, 2005. Accepted July 18, 2005.
The Transporter Classification Database (TCDB) is a web accessible, curated, relational database containing sequence, classification, structural, functional and evolutionary information about transport systems from a variety of living organisms. TCDB is a curated repository for factual information compiled from >10 000 references, encompassing 
3000 representative transporters and putative transporters, classified into >400 families. The transporter classification (TC) system is an International Union of Biochemistry and Molecular Biology approved system of nomenclature for transport protein classification. TCDB is freely accessible at http://www.tcdb.org. The web interface provides several different methods for accessing the data, including step-by-step access to hierarchical classification, direct search by sequence or TC number and full-text searching. The functional ontology that underlies the database structure facilitates powerful query searches that yield valuable data in a quick and easy way. The TCDB website also offers several tools specifically designed for analyzing the unique characteristics of transport proteins. TCDB not only provides curated information and a tool for classifying newly identified membrane proteins, but also serves as a genome transporter-annotation tool.
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