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The PROSITE database
Swiss Institute of Bioinformatics (SIB), Centre Medical Universitaire 1 rue Michel Servet, 1211 Geneva 4, Switzerland 1Swiss Institute of Bioinformatics (SIB), BEP-UNIL 1066 Lausanne, Switzerland
*To whom correspondence should be addressed. Tel: +41 22 379 58 72; Fax +41 22 379 58 58; Email: Nicolas.Hulo{at}isb-sib.ch
Received September 13, 2005. Revised October 7, 2005. Accepted October 7, 2005.
The PROSITE database consists of a large collection of biologically meaningful signatures that are described as patterns or profiles. Each signature is linked to a documentation that provides useful biological information on the protein family, domain or functional site identified by the signature. The PROSITE database is now complemented by a series of rules that can give more precise information about specific residues. During the last 2 years, the documentation and the ScanProsite web pages were redesigned to add more functionalities. The latest version of PROSITE (release 19.11 of September 27, 2005) contains 1329 patterns and 552 profile entries. Over the past 2 years more than 200 domains have been added, and now 52% of UniProtKB/Swiss-Prot entries (release 48.1 of September 27, 2005) have a cross-reference to a PROSITE entry. The database is accessible at http://www.expasy.org/prosite/.
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