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Nucleic Acids Research 2006 34(Database Issue):D261-D266; doi:10.1093/nar/gkj008
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Nucleic Acids Research, 2006, Vol. 34, Database issue D261-D266
© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Article

The EROP-Moscow oligopeptide database

Alexander A. Zamyatnin*, Alexander S. Borchikov, Michail G. Vladimirov and Olga L. Voronina

A.N. Bach Institute of Biochemistry, Russian Academy of Sciences 33 Leninsky prosp., Moscow 119071, Russian Federation

*To whom correspondence should be addressed. Tel: +7 095 9543066; Fax: +7 095 9542732; Email: aaz{at}inbi.ras.ru

Received July 29, 2005. Revised August 30, 2005. Accepted September 12, 2005.

Natural oligopeptides may regulate nearly all vital processes. To date, the chemical structures of nearly 6000 oligopeptides have been identified from >1000 organisms representing all the biological kingdoms. We have compiled the known physical, chemical and biological properties of these oligopeptides—whether synthesized on ribosomes or by non-ribosomal enzymes—and have constructed an internet-accessible database, EROP-Moscow (Endogenous Regulatory OligoPeptides), which resides at http://erop.inbi.ras.ru. This database enables users to perform rapid searches via many key features of the oligopeptides, and to carry out statistical analysis of all the available information. The database lists only those oligopeptides whose chemical structures have been completely determined (directly or by translation from nucleotide sequences). It provides extensive links with the Swiss-Prot-TrEMBL peptide-protein database, as well as with the PubMed biomedical bibliographic database. EROP-Moscow also contains data on many oligopeptides that are absent from other convenient databases, and is designed for extended use in classifying new natural oligopeptides and for production of novel peptide pharmaceuticals.


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