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The Gene Ontology (GO) project in 2006
GO-EBI, EMBL-EBI Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
Correspondence should be addressed to GO-EBI, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. Tel: +44 0 1223 494667; Fax: +44 0 1223 494468; Email: midori{at}ebi.ac.uk
Received September 8, 2005. Revised September 19, 2005. Accepted September 19, 2005.
The Gene Ontology (GO) project (http://www.geneontology.org) develops and uses a set of structured, controlled vocabularies for community use in annotating genes, gene products and sequences (also see http://song.sourceforge.net/). The GO Consortium continues to improve to the vocabulary content, reflecting the impact of several novel mechanisms of incorporating community input. A growing number of model organism databases and genome annotation groups contribute annotation sets using GO terms to GO's public repository. Updates to the AmiGO browser have improved access to contributed genome annotations. As the GO project continues to grow, the use of the GO vocabularies is becoming more varied as well as more widespread. The GO project provides an ontological annotation system that enables biologists to infer knowledge from large amounts of data.
*The current members of the GO Consortium are: Midori A. Harris, Jennifer I. Clark, Amelia Ireland, Jane Lomax (GO-EBI, Hinxton, UK); Michael Ashburner, Russell Collins (FlyBase, Department of Genetics, University of Cambridge, Cambridge, UK); Karen Eilbeck, Suzanna Lewis, Chris Mungall, John Richter, Gerald M. Rubin, ShengQiang Shu (BDGP, UC-Berkeley, Berkeley, CA, USA), Judith A. Blake, Carol J. Bult, Alexander D. Diehl, Mary E. Dolan, Harold J. Drabkin, Janan T. Eppig, David P. Hill, Li Ni, Martin Ringwald (MGI, The Jackson Laboratory, Bar Harbor, ME, USA); Rama Balakrishnan, Gail Binkley, J. Michael Cherry, Karen R. Christie, Maria C. Costanzo, Qing Dong, Stacia R. Engel, Dianna G. Fisk, Jodi E. Hirschman, Benjamin C. Hitz, Eurie L. Hong, Christopher Lane, Stuart Miyasato, Robert Nash, Anand Sethuraman, Marek Skrzypek, Chandra L. Theesfeld, Shuai Weng (SGD, Department of Genetics, Stanford University, Stanford, CA, USA); David Botstein, Kara Dolinski, Rose Oughtred (Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA); Tanya Berardini, Suparna Mundodi, Seung Y. Rhee (TAIR, Carnegie Institution, Department of Plant Biology, Stanford, CA, USA); Rolf Apweiler, Daniel Barrell, Evelyn Camon, Emily Dimmer, Nicola Mulder (GOA Database, UniProt, EBI, Hinxton, UK); Rex Chisholm, Petra Fey, Pascale Gaudet, Warren Kibbe, Karen Pilcher (DictyBase, Northwestern University, Chicago, IL, USA); Carol A. Bastiani, Ranjana Kishore, Erich M. Schwarz, Paul Sternberg, Kimberly Van Auken (WormBase, California Institute of Technology, Pasadena, CA, USA); Michelle Gwinn, Linda Hannick, Jennifer Wortman (The Institute for Genome Research, Rockville, MD, USA); Martin Aslett, Matthew Berriman, Valerie Wood (Wellcome Trust Sanger Institute, Hinxton, UK); Susan Bromberg, Cindy Foote, Howard Jacob, Dean Pasko, Victoria Petri, Dorothy Reilly, Kathy Seiler, Mary Shimoyama, Jennifer Smith, Simon Twigger (RGD, Medical College of Wisconsin, Milwaukee, WI, USA); Pankaj Jaiswal (Gramene, Department of Plant Breeding, Cornell University, Ithaca, NY, USA); Trent Seigfried (MaizeGDB, Iowa State University, Ames, IA, USA); Candace Collmer (Wells College, Aurora, NY, USA); Doug Howe, Monte Westerfield (ZFIN, University of Oregon, Eugene, OR, USA).
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