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Nucleic Acids Research 2006 34(Database Issue):D452-D455; doi:10.1093/nar/gkj041
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Nucleic Acids Research, 2006, Vol. 34, Database issue D452-D455
© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org


Article

Visualizing syntenic relationships among the hemiascomycetes with the Yeast Gene Order Browser

Kevin P. Byrne* and Kenneth H. Wolfe

Department of Genetics, Smurfit Institute, University of Dublin, Trinity College Dublin 2, Ireland

*To whom correspondence should be addressed. Tel: +353 1 608 1288; Fax: +353 1 679 8558; Email: kevin.byrne{at}tcd.ie

Received August 10, 2005. Revised October 3, 2005. Accepted October 3, 2005.

The Yeast Gene Order Browser (YGOB) is an online tool designed to facilitate the comparative genomic visualization and appraisal of synteny within and between the genomes of seven hemiascomycete yeast species. Three of these genomes are polyploid, and hence contain intra-genomic syntenic regions, the correct assembly of which is a particular success of YGOB. Designed to accurately assemble, display and score gene order relationships, YGOB is both an interactive tool for browsing genomic data, and a software engine now being used for evolutionary analyses on a whole-genome scale. Underlying the online interface is the YGOB database, which consists of homology assignments across the species, extensively curated based on sequence similarity and novelly, an appraisal of genomic context (synteny) in multiple genomes. Currently the YGOB database incorporates genome data from Saccharomyces cerevisiae, Candida glabrata, Saccharomyces castellii, Ashbya gossypii, Kluyveromyces lactis, Kluyveromyces waltii and Saccharomyces kluyveri, but the system is scaleable to accommodate additional genomes. This paper discusses the usage and utility of version 1.0 of YGOB, which is publicly available at http://wolfe.gen.tcd.ie/ygob.


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