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Nucleic Acids Research 2006 34(Database Issue):D489-D494; doi:10.1093/nar/gkj114
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Nucleic Acids Research, 2006, Vol. 34, Database issue D489-D494
© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Article

FlyRNAi: the Drosophila RNAi screening center database

Ian Flockhart1,*, Matthew Booker1, Amy Kiger3, Michael Boutros4, Susan Armknecht1, Nadire Ramadan1, Kris Richardson1, Andrew Xu1, Norbert Perrimon1,2 and Bernard Mathey-Prevot1

1Department of Genetics, Harvard Medical School Boston, MA 02115, USA 2Howard Hughes Medical Institute, Harvard Medical School Boston, MA 02115, USA 3Department of Biological Sciences, University of California-San Diego La Jolla, CA 92093-0346, USA 4German Cancer Research Center D-69120 Heidelberg, Germany

*To whom correspondence should be addressed. Tel: +1 617 432 0365; Fax: +1 617 432 6238; Email: iflockha{at}genetics.med.harvard.edu

Received August 10, 2005. Revised October 18, 2005. Accepted October 18, 2005.

RNA interference (RNAi) has become a powerful tool for genetic screening in Drosophila. At the Drosophila RNAi Screening Center (DRSC), we are using a library of over 21 000 double-stranded RNAs targeting known and predicted genes in Drosophila. This library is available for the use of visiting scientists wishing to perform full-genome RNAi screens. The data generated from these screens are collected in the DRSC database (http://flyRNAi.org/cgi-bin/RNAi_screens.pl) in a flexible format for the convenience of the scientist and for archiving data. The long-term goal of this database is to provide annotations for as many of the uncharacterized genes in Drosophila as possible. Data from published screens are available to the public through a highly configurable interface that allows detailed examination of the data and provides access to a number of other databases and bioinformatics tools.


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