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Nucleic Acids Research 2006 34(Database Issue):D602-D606; doi:10.1093/nar/gkj015
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Nucleic Acids Research, 2006, Vol. 34, Database issue D602-D606
© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Article

CTGA: the database for genetic disorders in Arab populations

Ghazi O. Tadmouri*, Mahmoud Taleb Al Ali, Sarah Al-Haj Ali and Najib Al Khaja

Centre for Arab Genomic Studies PO Box 22252, Dubai, United Arab Emirates

*To whom correspondence should be addressed. Tel: +971 4 398 6 777; Fax: +971 4 398 0 999; Email: tadmouri{at}hotmail.com, cags{at}emirates.net.ae

Received July 4, 2005. Revised September 17, 2005. Accepted September 17, 2005.

The Arabs comprise a genetically heterogeneous group that resulted from the admixture of different populations throughout history. They share many common characteristics responsible for a considerable proportion of perinatal and neonatal mortalities. To this end, the Centre for Arab Genomic Studies (CAGS) launched a pilot project to construct the ‘Catalogue of Transmission Genetics in Arabs’ (CTGA) database for genetic disorders in Arabs. Information in CTGA is drawn from published research and mined hospital records. The database offers web-based basic and advanced search approaches. In either case, the final search result is a detailed HTML record that includes text-, URL- and graphic-based fields. At present, CTGA hosts entries for 692 phenotypes and 235 related genes described in Arab individuals. Of these, 213 phenotypic descriptions and 22 related genes were observed in the Arab population of the United Arab Emirates (UAE). These results emphasize the role of CTGA as an essential tool to promote scientific research on genetic disorders in the region. The priority of CTGA is to provide timely information on the occurrence of genetic disorders in Arab individuals. It is anticipated that data from Arab countries other than the UAE will be exhaustively searched and incorporated in CTGA (http://www.cags.org.ae).


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