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Nucleic Acids Research 2006 34(Web Server issue):W225-W230; doi:10.1093/nar/gkl121
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© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Article

sgTarget: a target selection resource for structural genomics

Ana P. C. Rodrigues, Barry J. Grant and Roderick E. Hubbard*

Structural Biology Laboratory, University of York York YO10 5YW, UK

*To whom correspondence should be addressed. Tel: +44 1904 328267; Fax: +44 1904 328266; Email: rod{at}ysbl.york.ac.uk

Received February 14, 2006. Revised February 22, 2006. Accepted March 13, 2006.

sgTarget (http://www.ysbl.york.ac.uk/sgTarget) is a web-based resource to aid the selection and prioritization of candidate proteins for structure determination. The system annotates user submitted gene or protein sequences, identifying sequence families with no homologues of known structure, and characterizing each protein according to a range of physicochemical properties that may affect its expression, solubility and likelihood to crystallize. Summaries of these analyses are available for individual sequences, as well as whole datasets. This type of analysis enables structural biologists to iteratively select targets from their genomic sequences of interest and according to their research needs. All sequence datasets submitted to sgTarget are available for users to select and rank using their choice of criteria. sgTarget was developed to support individual laboratories collaborating in structural and functional genomics projects and should be valuable to structural biologists wishing to employ the wealth of available genome sequences in their structural quests.

Present addresses: Ana P. C. Rodrigues, Burnham Institute for Medical Research, La Jolla CA 92037, USA

Barry J. Grant, Department of Chemistry & Biochemistry, University of California San Diego, La Jolla CA 92037, USA


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