Skip Navigation

Nucleic Acids Research 2006 34(Web Server issue):W254-W257; doi:10.1093/nar/gkl207
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (135K) Freely available
Right arrow Screen PDF (117K) Freely available
Right arrow Supplementary Material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Xue, Y.
Right arrow Articles by Yao, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xue, Y.
Right arrow Articles by Yao, X.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Article

SUMOsp: a web server for sumoylation site prediction

Yu Xue1, Fengfeng Zhou2, Chuanhai Fu1,3, Ying Xu2,* and Xuebiao Yao1,3,*

1 Laboratory of Cellular Dynamics, Hefei National Laboratory for Physical Sciences, and the University of Science and Technology of China Hefei, China 230027 2 Computational Systems Biology Laboratory, Department of Biochemical and Molecular Biology, and Institute of Bioinformatics, University of Georgia Athens, GA 30602, USA 3 Department of Physiology and Cancer Research Program, Morehouse School of Medicine Atlanta, GA 30310, USA

*To whom correspondence should be addressed. Tel: +86 551 3606304; Fax: 001 404 752 1045; Email: yaoxb{at}ustc.edu.cn

*Correspondence may also be addressed to Ying Xu. Tel: +001 706 542 9779; Fax: +001 706 542 9751; Email: xyn{at}bmb.uga.edu

Received January 27, 2006. Revised March 13, 2006. Accepted March 22, 2006.

Systematic dissection of the sumoylation proteome is emerging as an appealing but challenging research topic because of the significant roles sumoylation plays in cellular dynamics and plasticity. Although several proteome-scale analyzes have been performed to delineate potential sumoylatable proteins, the bona fide sumoylation sites still remain to be identified. Previously, we carried out a genome-wide analysis of the SUMO substrates in human nucleus using the putative motif {psi}-K-X-E and evolutionary conservation. However, a highly specific predictor for in silico prediction of sumoylation sites in any individual organism is still urgently needed to guide experimental design. In this work, we present a computational system SUMOsp—SUMOylation Sites Prediction, based on a manually curated dataset, integrating the results of two methods, GPS and MotifX, which were originally designed for phosphorylation site prediction. SUMOsp offers at least as good prediction performance as the only available method, SUMOplot, on a very large test set. We expect that the prediction results of SUMOsp combined with experimental verifications will propel our understanding of sumoylation mechanisms to a new level. SUMOsp has been implemented on a freely accessible web server at: http://bioinformatics.lcd-ustc.org/sumosp/.

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J BiochemHome page
K. Schwamborn, P. Knipscheer, E. van Dijk, W. J. van Dijk, T. K. Sixma, R. H. Meloen, and J. P.M. Langedijk
SUMO Assay with Peptide Arrays on Solid Support: Insights into SUMO Target Sites
J. Biochem., July 1, 2008; 144(1): 39 - 49.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.