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Nucleic Acids Research 2006 34(Web Server issue):W264-W266; doi:10.1093/nar/gkl242
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© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article

DyNAVacS: an integrative tool for optimized DNA vaccine design

Nagarajan Harish, Rekha Gupta, Parul Agarwal1, Vinod Scaria2,* and Beena Pillai2,*

Indian Institute of Technology Madras Chennai 1 Department of Genetics, University of Delhi South Campus, Delhi, India 2 Institute of Genomics and Integrative Biology Delhi, India

*To whom correspondence should be addressed. Tel: +91 011 27666156, 27666157, 27667602, 27667439; Fax: +91 011 27667471; Email: beenapillai{at}igib.res.in

Received March 16, 2006. Revised March 20, 2006. Accepted March 29, 2006.

DNA vaccines have slowly emerged as keystones in preventive immunology due to their versatility in inducing both cell-mediated as well as humoral immune responses. The design of an efficient DNA vaccine, involves choice of a suitable expression vector, ensuring optimal expression by codon optimization, engineering CpG motifs for enhancing immune responses and providing additional sequence signals for efficient translation. DyNAVacS is a web-based tool created for rapid and easy design of DNA vaccines. It follows a step-wise design flow, which guides the user through the various sequential steps in the design of the vaccine. Further, it allows restriction enzyme mapping, design of primers spanning user specified sequences and provides information regarding the vectors currently used for generation of DNA vaccines. The web version uses Apache HTTP server. The interface was written in HTML and utilizes the Common Gateway Interface scripts written in PERL for functionality. DyNAVacS is an integrated tool consisting of user-friendly programs, which require minimal information from the user. The software is available free of cost, as a web based application at URL: http://miracle.igib.res.in/dynavac/.

*Correspondence may also be addressed to Vinod Scaria. Tel: +91 011 27666156; Fax: +91 011 27667471; Email: vinods{at}igib.res.in

{dagger}The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors


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