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Nucleic Acids Research 2006 34(Web Server issue):W588-W590; doi:10.1093/nar/gkl313
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© The Author 2006. Published by Oxford University Press. All rights reserved
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Article

TICO: a tool for postprocessing the predictions of prokaryotic translation initiation sites

M. Tech*, B. Morgenstern and P. Meinicke

Abteilung Bioinformatik, Institut für Mikrobiologie und Genetik Georg-August-Universität Göttingen, Goldschmidtstrasse 1, 37077 Göttingen, Germany

*To whom correspondence should be addressed. Tel: +49 551 3914927; Fax: +49 551 3914929; E-mail: maike{at}gobics.de

Received February 14, 2006. Revised March 6, 2006. Accepted April 11, 2006.

Exact localization of the translation initiation sites (TIS) in prokaryotic genomes is difficult to achieve using conventional gene finders. We recently introduced the program TICO for postprocessing TIS predictions based on a completely unsupervised learning algorithm. The program can be utilized through our web interface at http://tico.gobics.de/ and it is also freely available as a commandline version for Linux and Windows. The latest version of our program provides a tool for visualization of the resulting TIS model. Although the underlying method is not based on any specific assumptions about characteristic sequence features of prokaryotic TIS the prediction rates of our tool are competitive on experimentally verified test data.


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