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Nucleic Acids Research 2006 34(Web Server issue):W725-W728; doi:10.1093/nar/gkl196
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© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Article

metaSHARK: a WWW platform for interactive exploration of metabolic networks

Christopher Hyland, John W. Pinney1,*, Glenn A. McConkey and David R. Westhead

Faculty of Biological Sciences, University of Leeds Clarendon Way, Leeds LS2 9JT, UK 1 Faculty of Life Sciences, University of Manchester Oxford Road, Manchester M13 9PT, UK

*To whom correspondence should be addressed. Tel: +44 0 161 275 1566; Fax: +44 0 161 275 5082; Email: john.pinney{at}manchester.ac.uk

Received February 14, 2006. Revised March 21, 2006. Accepted March 21, 2006.

The metaSHARK (metabolic search and reconstruction kit) web server offers users an intuitive, fully interactive way to explore the KEGG metabolic network via a WWW browser. Metabolic reconstruction information for specific organisms, produced by our automated SHARKhunt tool or from other programs or genome annotations, may be uploaded to the website and overlaid on the generic network. Additional data from gene expression experiments can also be incorporated, allowing the visualization of differential gene expression in the context of the predicted metabolic network. metaSHARK is available at http://bioinformatics.leeds.ac.uk/shark/.

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors


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