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Nucleic Acids Research 2006 34(Web Server issue):W79-W83; doi:10.1093/nar/gkl216
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© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Article

ProSAT2—Protein Structure Annotation Server

R. R. Gabdoulline*, S. Ulbrich, S. Richter and R. C. Wade

Molecular and Cellular Modeling Group, EML Research Schloss-Wolfsbrunnenweg 33, 69118 Heidelberg, Germany

*To whom correspondence should be addressed. Tel: +49 6221 533 266; Fax: +49 6221 533 298; Email: razif.gabdoulline{at}eml-r.villa-bosch.de

Received February 14, 2006. Revised March 24, 2006. Accepted March 24, 2006.

ProSAT2 is a server to facilitate interactive visualization of sequence-based, residue-specific annotations mapped onto 3D protein structures. As the successor of ProSAT (Protein Structure Annotation Tool), it includes its features for visualizing SwissProt and PROSITE functional annotations. Currently, the ProSAT2 server can perform automated mapping of information on variants and mutations from the UniProt KnowledgeBase and the BRENDA enzyme information system onto protein structures. It also accepts and maps user-prepared annotations. By means of an annotation selector, the user can interactively select and group residue-based information according to criteria such as whether a mutation affects enzyme activity. The visualization of the protein structures is based on the WebMol Java molecular viewer and permits simultaneous highlighting of annotated residues and viewing of the corresponding descriptive texts. ProSAT2 is available at http://projects.villa-bosch.de/mcm/database/prosat2/.


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