Article |
ProKware: integrated software for presenting protein structural properties in protein tertiary structures
1 Institute of Bioinformatics, National Chiao Tung University Hsin-Chu 300, Taiwan 2 Department of Biological Science and Technology, National Chiao Tung University Hsin-Chu 300, Taiwan 3 Core Facility for Structural Bioinformatics, National Chiao Tung University Hsin-Chu, Taiwan
To whom correspondence should be addressed. Tel: +886 3 571 2121, ext. 56952; Fax: +886 3 572 9288; Email: bryan{at}mail.nctu.edu.tw
Received February 14, 2006. Revised March 6, 2006. Accepted March 28, 2006.
Protein tertiary structure plays an essential role in deciphering protein functions, especially protein structural properties, including domains, active sites and post-translational modifications. These properties typically yield useful clues for understanding protein functions. This work presents an integrated software, named ProKware, that presents protein structural properties in protein tertiary structures, such as domains, functional sites, families, active sites, binding sites, post-translational modifications and domaindomain interaction. Using this web-based and Windows-based interface, users can manipulate and visualize three-dimensional protein structures, as well as the supported structural properties that are curated in the protein knowledge database. ProKware is an effective and convenient solution for investigating protein functions and structural relationships. This software can be accessed on the internet at http://ProKware.mbc.nctu.edu.tw/.
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.