Nucleic Acids Research Advance Access originally published online on December 7, 2006
Nucleic Acids Research 2007 35(1):152-164; doi:10.1093/nar/gkl1032
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Nucleic Acids Research, 2007, Vol. 35, No. 1 152-164
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Computational Biology |
Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos
Mammalian Cell Genetics Group, Biotechnology Research Institute, National Research Council Canada Montreal, Quebec, H4P 2R2, Canada 1 Computational Chemistry & Biology Group, Biotechnology Research Institute, National Research Council Canada Montreal, Quebec, H4P 2R2, Canada
*To whom correspondence should be addressed. Tel: +514 496 6377; Fax: +514 496 6319; Email: zhenbao.yu{at}nrc.ca
*Correspondence may also be addressed to Edwin Wang. Tel: +514 496 0914; Fax: +514 496 5143; Email: edwin.wang{at}cnrc-nrc.gc.ca
Received June 29, 2006. Revised September 27, 2006. Accepted October 19, 2006.
MicroRNAs (miRNAs) are non-coding small RNAs of 
22 nt that regulate the gene expression by base pairing with target mRNAs, leading to mRNA cleavage or translational repression. It is currently estimated that miRNAs account for 1% of predicted genes in higher eukaryotic genomes and that up to 30% of genes might be regulated by miRNAs. However, only very few miRNAs have been functionally characterized and the general functions of miRNAs are not globally studied. In this study, we systematically analyzed the expression patterns of miRNA targets using several public microarray profiles. We found that the expression levels of miRNA targets are lower in all mouse and Drosophila tissues than in the embryos. We also found miRNAs more preferentially target ubiquitously expressed genes than tissue-specifically expressed genes. These results support the current suggestion that miRNAs are likely to be largely involved in embryo development and maintaining of tissue identity.
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