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Nucleic Acids Research Advance Access originally published online on June 18, 2007
Nucleic Acids Research 2007 35(13):4223-4237; doi:10.1093/nar/gkm389
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Nucleic Acids Research, 2007, Vol. 35, No. 13 4223-4237
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Miniaturized PCR chips for nucleic acid amplification and analysis: latest advances and future trends

Chunsun Zhang and Da Xing*

MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou 510631, China

*To whom correspondence should be addressed. Tel: +86 20 85210089; Fax: +86 20 85216052; Email: xingda{at}scnu.edu.cn

Received November 14, 2006. Revised April 28, 2007. Accepted April 29, 2007.

The possibility of performing fast and small-volume nucleic acid amplification and analysis on a single chip has attracted great interest. Devices based on this idea, referred to as micro total analysis, microfluidic analysis, or simply ‘Lab on a chip’ systems, have witnessed steady advances over the last several years. Here, we summarize recent research on chip substrates, surface treatments, PCR reaction volume and speed, architecture, approaches to eliminating cross-contamination and control and measurement of temperature and liquid flow. We also discuss product-detection methods, integration of functional components, biological samples used in PCR chips, potential applications and other practical issues related to implementation of lab-on-a-chip technologies.


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