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Nucleic Acids Research Advance Access originally published online on October 2, 2007
Nucleic Acids Research 2007 35(22):7399-7405; doi:10.1093/nar/gkm635
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Nucleic Acids Research, 2007, Vol. 35, No. 22 7399-7405
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Survey and Summary

The ageing mitochondrial genome

Kim J. Krishnan*, Laura C. Greaves, Amy K. Reeve and Doug Turnbull

Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry and Institute for Ageing and Health, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK

*To whom correspondence should be addressed. Tel: +44(0)1912227051; Fax: +44(0)1912228553; Email: k.j.krishnan{at}ncl.ac.uk

Correspondence may also be addressed to Doug Turnbull. Tel: +44(0)1912228565; Fax: +44(0)1912228553; Email: d.m.turnbull{at}ncl.ac.uk

Received July 6, 2007. Revised August 2, 2007. Accepted August 2, 2007.

The population of elderly individuals has increased significantly over the past century and is predicted to rise even more rapidly in the future. Ageing is a major risk factor for many diseases such as neurodegenerative disease, diabetes and cancer. This highlights the importance of understanding the mechanisms involved in the ageing process. One plausible mechanism for ageing is accumulation of mutations in the mitochondrial genome. In this review, we discuss some of the most convincing data surrounding age-related mtDNA mutations and the evidence that these mutations contribute to the ageing process.


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