Nucleic Acids Research Advance Access originally published online on November 15, 2007
Nucleic Acids Research 2007 35(22):7527-7544; doi:10.1093/nar/gkm1008
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Nucleic Acids Research, 2007, Vol. 35, No. 22 7527-7544
© 2007
The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Human premature aging, DNA repair and RecQ helicases
Laboratory of Molecular Gerontology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
*To whom correspondence should be addressed. Tel: 410 558 8162; Fax: 410 558 8157; Email: vbohr{at}nih.gov
Received August 28, 2007. Revised October 24, 2007. Accepted October 24, 2007.
Genomic instability leads to mutations, cellular dysfunction and aberrant phenotypes at the tissue and organism levels. A number of mechanisms have evolved to cope with endogenous or exogenous stress to prevent chromosomal instability and maintain cellular homeostasis. DNA helicases play important roles in the DNA damage response. The RecQ family of DNA helicases is of particular interest since several human RecQ helicases are defective in diseases associated with premature aging and cancer. In this review, we will provide an update on our understanding of the specific roles of human RecQ helicases in the maintenance of genomic stability through their catalytic activities and protein interactions in various pathways of cellular nucleic acid metabolism with an emphasis on DNA replication and repair. We will also discuss the clinical features of the premature aging disorders associated with RecQ helicase deficiencies and how they relate to the molecular defects.
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