Nucleic Acids Research Advance Access originally published online on November 16, 2006
Nucleic Acids Research 2007 35(Database issue):D193-D197; doi:10.1093/nar/gkl929
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Nucleic Acids Research, 2007, Vol. 35, Database issue D193-D197
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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The Universal Protein Resource (UniProt)
1 Protein Information Resource, Georgetown University Medical Center, 3300 Whitehaven St. NW, Suite 1200 Washington, DC 20007, USA 2 The EMBL Outstation, The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Cambridge CB10 1SD, UK 3 Swiss Institute of Bioinformatics, Centre Medical Universitaire 1 rue Michel Servet 1211 Geneva 4, Switzerland
To whom correspondence should be addressed to Rolf Apweiler. Tel: +44 1223 494435; Fax: +44 1223 494468; Email: rolf.apweiler{at}ebi.ac.uk
Received September 21, 2006. Accepted October 12, 2006.
The ability to store and interconnect all available information on proteins is crucial to modern biological research. Accordingly, the Universal Protein Resource (UniProt) plays an increasingly important role by providing a stable, comprehensive, freely accessible central resource on protein sequences and functional annotation. UniProt is produced by the UniProt Consortium, formed in 2002 by the European Bioinformatics Institute (EBI), the Protein Information Resource (PIR) and the Swiss Institute of Bioinformatics (SIB). The core activities include manual curation of protein sequences assisted by computational analysis, sequence archiving, development of a user-friendly UniProt web site and the provision of additional value-added information through cross-references to other databases. UniProt is comprised of three major components, each optimized for different uses: the UniProt Archive, the UniProt Knowledgebase and the UniProt Reference Clusters. An additional component consisting of metagenomic and environmental sequences has recently been added to UniProt to ensure availability of such sequences in a timely fashion. UniProt is updated and distributed on a bi-weekly basis and can be accessed online for searches or download at http://www.uniprot.org.
The UniProt Consortium: Amos Bairoch, Lydie Bougueleret, Severine Altairac, Valeria Amendolia, Andrea Auchincloss, Ghislaine Argoud Puy, Kristian Axelsen, Delphine Baratin, Marie-Claude Blatter, Brigitte Boeckmann, Laurent Bollondi, Emmanuel Boutet, Silvia Braconi Quintaje, Lionel Breuza, Alan Bridge, Edouard deCastro, Danielle Coral, Elisabeth Coudert, Isabelle Cusin, Pavel Dobrokhotov, Dolnide Dornevil, Severine Duvaud, Anne Estreicher, Livia Famiglietti, Marc Feuermann, Sebastian Gehant, Nathalie Farriol-Mathis, Serenella Ferro, Elisabeth Gasteiger, Alain Gateau, Vivienne Gerritsen, Arnaud Gos, Nadine Gruaz-Gumowski, Ursula Hinz, Chantal Hulo, Nicolas Hulo, Vassilios Ioannidis, Ivan Ivanyi, Janet James, Eric Jain, Silvia Jimenez, Florence Jungo, Vivien Junker, Guillaume Keller, Corinne Lachaize, Lydie Lane-Guermonprez, Petra Langendijk-Genevaux, Vicente Lara, Philippe Lemercier, Virginie Le Saux, Damien Lieberherr, Tania de Oliveira Lima, Veronique Mangold, Xavier Martin, Karine Michoud, Madelaine Moinat, Cristiano Moreira, Anne Morgat, Marisa Nicolas, Shoko Ohji, Salvo Paesano, Ivo Pedruzzi, David Perret, Isabelle Phan, Sandrine Pilbout, Violaine Pillet, Sylvain Poux, Nicole Redaschi, Sorogini Reynaud, Catherine Rivoire, Bernd Roechert, Claudia Sapsezian, Michel Schneider, Christian Sigrist, Mauricio da Silva, Karin Sonesson, Andre Stutz, Shyamala Sundaram, Michael Tognolli, Laure Verbregue, Anne-Lise Veuthey, Claudia Vitorello and Lina Yip at the Swiss Institute of Bioinformatics (SIB) and the Medical Biochemistry Department of the University of Geneva; Rolf Apweiler, Yasmin Alam-Faruque, Daniel Barrell, Lawrence Bower, Paul Browne, Wei Mun Chan, Louise Daugherty, Emilio Salazar Donate, Ruth Eberhardt, Alexander Fedotov, Rebecca Foulger, Gill Fraser, Gabriella Frigerio, John Garavelli, Renato Golin, Alan Horne, Julius Jacobsen, Michael Kleen, Paul Kersey, Ernst Kretschmann, Kati Laiho, Rasko Leinonen, Duncan Legge, Michele Magrane, Maria Jesus Martin, Patricia Monteiro, Claire O'Donovan, Sandra Orchard, John O'Rourke, Samuel Patient, Manuela Pruess, Andrey Sitnov, Nataliya Sklyar, Eleanor Whitfield, Daniela Wieser, Quan Lin, Mark Rynbeek, Giuseppe di Martino, Mike Donnelly and Pieter van Rensburg at the European Bioinformatics Institute (EBI). Cathy Wu, Cecilia Arighi, Leslie Arminski, Winona Barker, Yongxing Chen, Sehee Chung, Christina Fang, Vincent Hermoso, Zhang-Zhi Hu, Hsing-Kuo Hua, Hongzhan Huang, Robel Kahsay, Raja Mazumder, Peter McGarvey, Darren Natale, Anastasia Nikolskaya, Natalia Petrova, Baris Suzek, Sona Vasudevan, C. R. Vinayaka, Lai Su Yeh, Xin Yuan and Jian Zhang at the Protein Information Resource (PIR)
The authors wish it to be know that, in their opinion, all authors should be regarded as joint First Authors
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