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Nucleic Acids Research Advance Access originally published online on November 16, 2006
Nucleic Acids Research 2007 35(Database issue):D363-D366; doi:10.1093/nar/gkl970
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Nucleic Acids Research, 2007, Vol. 35, Database issue D363-D366
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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euHCVdb: the European hepatitis C virus database

Christophe Combet*, Nicolas Garnier, Céline Charavay, Delphine Grando, Daniel Crisan, Julien Lopez, Alexandre Dehne-Garcia, Christophe Geourjon, Emmanuel Bettler, Chantal Hulo1, Philippe Le Mercier1, Ralf Bartenschlager2, Helmut Diepolder3, Darius Moradpour4, Jean-Michel Pawlotsky5, Charles M. Rice6, Christian Trépo7, François Penin and Gilbert Deléage

Institut de Biologie et Chimie des Protéines (UMR5086), CNRS, University of Lyon 1 IFR 128 BioSciences Lyon-Gerland, France 1 Swiss Institute of Bioinformatics, Geneva Switzerland 2 Department for Molecular Virology, University of Heidelberg Germany 3 Institute for Immunology, University of Munich Germany 4 Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne Switzerland 5 Department of Virology, INSERM U635, Henri Mondor Hospital, University of Paris XII Creteil, France 6 Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University New York, NY 7 INSERM U271 Lyon, France

*To whom correspondence should be addressed. Tel: +33 4 37 65 29 47; Fax: +33 4 72 72 26 04; Email: c.combet{at}ibcp.fr

Received August 10, 2006. Accepted October 20, 2006.

The hepatitis C virus (HCV) genome shows remarkable sequence variability, leading to the classification of at least six major genotypes, numerous subtypes and a myriad of quasispecies within a given host. A database allowing researchers to investigate the genetic and structural variability of all available HCV sequences is an essential tool for studies on the molecular virology and pathogenesis of hepatitis C as well as drug design and vaccine development. We describe here the European Hepatitis C Virus Database (euHCVdb, http://euhcvdb.ibcp.fr), a collection of computer-annotated sequences based on reference genomes. The annotations include genome mapping of sequences, use of recommended nomenclature, subtyping as well as three-dimensional (3D) molecular models of proteins. A WWW interface has been developed to facilitate database searches and the export of data for sequence and structure analyses. As part of an international collaborative effort with the US and Japanese databases, the European HCV Database (euHCVdb) is mainly dedicated to HCV protein sequences, 3D structures and functional analyses.

Members of the euHCVdb Scientific Board: Ralf Bartenschlager, Helmut Diepolder, Darius Moradpour, Jean-Michel Pawlotsky, Charles M. Rice, Christian Trépo and François Penin


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