Nucleic Acids Research Advance Access originally published online on December 5, 2006
Nucleic Acids Research 2007 35(Database issue):D381-D385; doi:10.1093/nar/gkl1009
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Nucleic Acids Research, 2007, Vol. 35, Database issue D381-D385
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Articles |
ViTa: prediction of host microRNAs targets on viruses
1 Institute of Bioinformatics, National Chiao Tung University Hsin-Chu 300, Taiwan, ROC 2 Department of Biological Science and Technology, National Chiao Tung University Hsin-Chu 300, Taiwan, ROC 3 Core Facility for Structural Bioinformatics, National Chiao Tung University Hsin-Chu 300, Taiwan, ROC
*To whom correspondence should be addressed. Tel: +886 3 5712121, ext. 56952; Fax: +886 3 5729288; Email: bryan{at}mail.nctu.edu.tw
Received August 17, 2006. Revised October 30, 2006. Accepted October 31, 2006.
MicroRNAs (miRNAs) are involved in various biological processes by suppressing gene expression. A recent work has indicated that host miRNAs are also capable of regulating viral gene expression by targeting the virus genomes. To investigate regulatory relationships between host miRNAs and related viruses, we present a novel database, namely ViTa, to curate the known virus miRNA genes and the known/putative target sites of human, mice, rat and chicken miRNAs. Known miRNAs are obtained from miRBase. Virus data are collected and referred from ICTVdB, VBRC and VirGen. Experimentally validated miRNA targets on viruses were derived from literatures. Then, miRanda and TargetScan are utilized to predict miRNA targets within virus genomes. ViTa also provides the virus annotations, virus-infected tissues and tissue specificity of host miRNAs. This work also facilitates the comparisons between subtypes of viruses, such as influenza viruses, human liver viruses and the conserved regions between viruses. Both textual and graphical web interfaces are provided to facilitate the data retrieves in the ViTa database. The database is now freely available at http://vita.mbc.nctu.edu.tw/.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C.J. Carter Schizophrenia Susceptibility Genes Directly Implicated in the Life Cycles of Pathogens: Cytomegalovirus, Influenza, Herpes simplex, Rubella, and Toxoplasma gondii Schizophr Bull, November 1, 2009; 35(6): 1163 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shilo, S. Roy, S. Khanna, and C. K. Sen Evidence for the Involvement of miRNA in Redox Regulated Angiogenic Response of Human Microvascular Endothelial Cells Arterioscler Thromb Vasc Biol, March 1, 2008; 28(3): 471 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-C. Li, C.-K. Shiau, and W.-c. Lin Vir-Mir db: prediction of viral microRNA candidate hairpins Nucleic Acids Res., January 11, 2008; 36(suppl_1): D184 - D189. [Abstract] [Full Text] [PDF]
|
|