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Nucleic Acids Research Advance Access originally published online on November 3, 2006
Nucleic Acids Research 2007 35(Database issue):D47-D50; doi:10.1093/nar/gkl807
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Nucleic Acids Research, 2007, Vol. 35, Database issue D47-D50
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Articles

Patome: a database server for biological sequence annotation and analysis in issued patents and published patent applications

Byungwook Lee1,2,*, Taehyung Kim1, Seon-Kyu Kim1, Kwang H. Lee2 and Doheon Lee2

1 Korean BioInformation Center, KRIBB Daejeon 305-806, Korea 2 Department of BioSystems, KAIST Daejeon 305-701, Korea

*To whom correspondence should be addressed. Tel: +82 42 879 8535; Fax: +82 42 879 8519; Email: bulee{at}kribb.re.kr

Received August 14, 2006. Revised September 23, 2006. Accepted September 29, 2006.

With the advent of automated and high-throughput techniques, the number of patent applications containing biological sequences has been increasing rapidly. However, they have attracted relatively little attention compared to other sequence resources. We have built a database server called Patome, which contains biological sequence data disclosed in patents and published applications, as well as their analysis information. The analysis is divided into two steps. The first is an annotation step in which the disclosed sequences were annotated with RefSeq database. The second is an association step where the sequences were linked to Entrez Gene, OMIM and GO databases, and their results were saved as a gene–patent table. From the analysis, we found that 55% of human genes were associated with patenting. The gene–patent table can be used to identify whether a particular gene or disease is related to patenting. Patome is available at http://www.patome.org/; the information is updated bimonthly.


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