Nucleic Acids Research Advance Access originally published online on December 14, 2006
Nucleic Acids Research 2007 35(Database issue):D742-D746; doi:10.1093/nar/gkl933
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Nucleic Acids Research, 2007, Vol. 35, Database issue D742-D746
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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T1DBase: integration and presentation of complex data for type 1 diabetes research
Institute for Systems Biology Seattle, WA, USA 1 Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge Cambridge, UK 2 Laboratory of Experimental Medicine, Free University of Brussels (ULB) Brussels, Belgium 3 Center for Human Genomics, Wake Forest University School of Medicine Winston-Salem, NC, USA
*To whom correspondence should be addressed. Tel: +1 206 331 0077; Fax: +1 206 363 0431; Email: EHulbert{at}systemsbiology.org
Received September 12, 2006. Revised October 11, 2006. Accepted October 12, 2006.
T1DBase (http://T1DBase.org) [Smink et al. (2005) Nucleic Acids Res., 33, D544–D549; Burren et al. (2004) Hum. Genomics, 1, 98–109] is a public website and database that supports the type 1 diabetes (T1D) research community. T1DBase provides a consolidated T1D-oriented view of the complex data world that now confronts medical researchers and enables scientists to navigate from information they know to information that is new to them. Overview pages for genes and markers summarize information for these elements. The Gene Dossier summarizes information for a list of genes. GBrowse [Stein et al. (2002) Genome Res., 10, 1599–1610] displays genes and other features in their genomic context, and Cytoscape [Shannon et al. (2003) Genome Res., 13, 2498–2504] shows genes in the context of interacting proteins and genes. The Beta Cell Gene Atlas shows gene expression in ß cells, islets, and related cell types and lines, and the Tissue Expression Viewer shows expression across other tissues. The Microarray Viewer shows expression from more than 20 array experiments. The Beta Cell Gene Expression Bank contains manually curated gene and pathway annotations for genes expressed in ß cells. T1DMart is a query tool for markers and genotypes. PosterPages are ‘home pages’ about specific topics or datasets. The key challenge, now and in the future, is to provide powerful informatics capabilities to T1D scientists in a form they can use to enhance their research.
*Correspondence may also be addressed to Luc J. Smink. Tel: +1 206 732 1200; Fax: +1 206 732 1299; Email: Luc.Smink{at}cimr.cam.ac.uk
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.
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