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Nucleic Acids Research Advance Access originally published online on August 1, 2008
Nucleic Acids Research 2008 36(16):5123-5138; doi:10.1093/nar/gkn493
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Nucleic Acids Research, 2008, Vol. 36, No. 16 5123-5138
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Survey and Summary

The triple helix: 50 years later, the outcome

Maria Duca1, Pierre Vekhoff2,3,4, Kahina Oussedik2,3,4, Ludovic Halby2,3 and Paola B. Arimondo2,3,*

1LCMBA CNRS UMR6001, University of Nice-Sophia Antipolis, Parc Valrose, 06108 NICE Cedex 2, 2UMR 5153 CNRS, Muséum National d’Histoire Naturelle USM0503, 3INSERM UR565, 43 rue Cuvier, 75231 Paris Cedex 05 and 4University Pierre et Marie Curie, Paris 75005, France

*To whom correspondence should be addressed. Tel: +33 1 40793859; Fax: +33 1 40793705; Email: arimondo{at}mnhn.fr

Received June 18, 2008. Revised July 14, 2008. Accepted July 16, 2008.

Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a chosen site on the DNA. They are not only used as biotechnological tools but also to induce modifications on DNA with the aim to control gene expression, such as by site-directed mutagenesis or DNA recombination. Here, we report the state of art of the triplex-based anti-gene strategy 50 years after the discovery of such a structure, and we show the importance of the actual applications and the main challenges that we still have ahead of us.


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