Nucleic Acids Research Advance Access originally published online on November 27, 2007
Nucleic Acids Research 2008 36(Database issue):D190-D195; doi:10.1093/nar/gkm895
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Nucleic Acids Research, 2008, Vol. 36, Database issue D190-D195
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]
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The Universal Protein Resource (UniProt)
The EMBL Outstation, The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, Protein Information Resource, Georgetown University Medical Center, 3300 Whitehaven St. NW, Suite 1200, Washington, DC 20007, USA and Swiss Institute of Bioinformatics, Centre Medical Universitaire 1 rue Michel Servet, 1211 Geneva 4, Switzerland
*To whom correspondence should be addressed. Tel: +44 1223 494435; Fax: +44 1223 494468; Email: apweiler{at}ebi.ac.uk
Received September 17, 2007. Revised October 3, 2007. Accepted October 3, 2007.
The Universal Protein Resource (UniProt) provides a stable, comprehensive, freely accessible, central resource on protein sequences and functional annotation. The UniProt Consortium is a collaboration between the European Bioinformatics Institute (EBI), the Protein Information Resource (PIR) and the Swiss Institute of Bioinformatics (SIB). The core activities include manual curation of protein sequences assisted by computational analysis, sequence archiving, development of a user-friendly UniProt website, and the provision of additional value-added information through cross-references to other databases. UniProt is comprised of four major components, each optimized for different uses: the UniProt Knowledgebase, the UniProt Reference Clusters, the UniProt Archive and the UniProt Metagenomic and Environmental Sequences database. UniProt is updated and distributed every three weeks, and can be accessed online for searches or download at http://www.uniprot.org.
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