Nucleic Acids Research Advance Access originally published online on December 23, 2007
Nucleic Acids Research 2008 36(Database issue):D196-D201; doi:10.1093/nar/gkm980
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Nucleic Acids Research, 2008, Vol. 36, Database issue D196-D201
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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MIPS: analysis and annotation of genome information in 2007
1Institute for Bioinformatics (MIPS), German Research Center for Environmental Health, Ingolstaedter Landstraße 1, D-85764 Neuherberg and 2Technische Universität München, Chair of Genome Oriented Bioinformatics, Center of Life and Food Science, D-85350 Freising-Weihenstephan, Germany
*To whom correspondence should be addressed. Tel: +49 89 3187 3580; Fax: +49 89 3187 3585; Email: w.mewes{at}gsf.de
Received September 15, 2007. Revised October 17, 2007. Accepted October 18, 2007.
The Munich Information Center for Protein Sequences (MIPS-GSF, Neuherberg, Germany) combines automatic processing of large amounts of sequences with manual annotation of selected model genomes. Due to the massive growth of the available data, the depth of annotation varies widely between independent databases. Also, the criteria for the transfer of information from known to orthologous sequences are diverse. To cope with the task of global in-depth genome annotation has become unfeasible. Therefore, our efforts are dedicated to three levels of annotation: (i) the curation of selected genomes, in particular from fungal and plant taxa (e.g. CYGD, MNCDB, MatDB), (ii) the comprehensive, consistent, automatic annotation employing exhaustive methods for the computation of sequence similarities and sequence-related attributes as well as the classification of individual sequences (SIMAP, PEDANT and FunCat) and (iii) the compilation of manually curated databases for protein interactions based on scrutinized information from the literature to serve as an accepted set of reliable annotated interaction data (MPACT, MPPI, CORUM). All databases and tools described as well as the detailed descriptions of our projects can be accessed through the MIPS web server (http://mips.gsf.de).
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