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Nucleic Acids Research Advance Access originally published online on October 25, 2007
Nucleic Acids Research 2008 36(Database issue):D240-D244; doi:10.1093/nar/gkm772
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Nucleic Acids Research, 2008, Vol. 36, Database issue D240-D244
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-com

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

Phospho.ELM: a database of phosphorylation sites—update 2008

Francesca Diella1, Cathryn M. Gould1, Claudia Chica1, Allegra Via2 and Toby J. Gibson1,*

1Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany and 2Center for Molecular Bioinformatics, Dept. of Biology, Tor Vergata University, Rome, Italy

* To whom correspondence should be addressed. Tel: +49 6221 3878398; Fax: +49 6221 3878517; Email: toby.gibson{at}embl.de

Received July 18, 2007. Revised September 4, 2007. Accepted September 13, 2007.

Phospho.ELM is a manually curated database of eukaryotic phosphorylation sites. The resource includes data collected from published literature as well as high-throughput data sets.

The current release of Phospho.ELM (version 7.0, July 2007) contains 4078 phospho-protein sequences covering 12 025 phospho-serine, 2362 phospho-threonine and 2083 phospho-tyrosine sites. The entries provide information about the phosphorylated proteins and the exact position of known phosphorylated instances, the kinases responsible for the modification (where known) and links to bibliographic references. The database entries have hyperlinks to easily access further information from UniProt, PubMed, SMART, ELM, MSD as well as links to the protein interaction databases MINT and STRING.

A new BLAST search tool, complementary to retrieval by keyword and UniProt accession number, allows users to submit a protein query (by sequence or UniProt accession) to search against the curated data set of phosphorylated peptides.

Phospho.ELM is available on line at: http://phospho.elm.eu.org


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