Nucleic Acids Research Advance Access originally published online on October 2, 2007
Nucleic Acids Research 2008 36(Database issue):D326-D331; doi:10.1093/nar/gkm792
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Nucleic Acids Research, 2008, Vol. 36, Database issue D326-D331
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]
Articles |
NORINE: a database of nonribosomal peptides
1Computer Science Laboratory of Lille (UMR USTL/CNRS 8022) and INRIA, and 2ProBioGEM (UPRES EA 1026), University of Sciences and Technologies of Lille, 59655 Villeneuve d'A;scq, France
*To whom correspondence should be addressed. Tel: +33 3 59 57 79 17; Fax: +33 3 28 77 85 37; Email: caboche{at}lifl.fr
Received August 14, 2007. Revised September 17, 2007. Accepted September 17, 2007.
Norine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent pathway called NRP synthesis allows peptide production. It is performed by huge protein complexes called nonribosomal peptide synthetases (NRPSs). The molecules synthesized by NRPS contain a high proportion of nonproteogenic amino acids. The primary structure of these peptides is not always linear but often more complex and may contain cycles and branchings. In recent years, NRPs attracted a lot of attention because of their biological activities and pharmacological properties (antibiotic, immunosuppressor, antitumor, etc.). However, few computational resources and tools dedicated to those peptides have been available so far. Norine is focused on NRPs and contains more than 700 entries. The database is freely accessible at http://bioinfo.lifl.fr/norine/. It provides a complete computational tool for systematic study of NRPs in numerous species, and as such, should permit to obtain a better knowledge of these metabolic products and underlying biological mechanisms, and ultimately to contribute to the redesigning of natural products in order to obtain new bioactive compounds for drug discovery.
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