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Nucleic Acids Research Advance Access originally published online on December 11, 2007
Nucleic Acids Research 2008 36(Database issue):D339-D343; doi:10.1093/nar/gkm700
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Nucleic Acids Research, 2008, Vol. 36, Database issue D339-D343
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

The Telomerase Database

Joshua D. Podlevsky1, Christopher J. Bley2, Rebecca V. Omana2, Xiaodong Qi2 and Julian J.-L. Chen1,2,*

1School of Life Sciences and 2Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA

*To whom correspondence should be addressed. Tel: +1 480 965 3650; Fax: +1 480 965 2747; Email: jlchen{at}asu.edu

Received August 14, 2007. Revised August 21, 2007. Accepted August 22, 2007.

Telomerase is a ribonucleoprotein enzyme that extends DNA at the chromosome ends in most eukaryotes. Since 1985, telomerase has been studied intensively and components of the telomerase complex have been identified from over 160 eukaryotic species. In the last two decades, there has been a growing interest in studying telomerase owing to its vital role in chromosome stability and cellular immortality. To keep up with the remarkable explosion of knowledge about telomerase, we compiled information related to telomerase in an exhaustive database called the Telomerase Database (http://telomerase.asu.edu/). The Telomerase Database provides comprehensive information about (i) sequences of the RNA and protein subunits of telomerase, (ii) sequence alignments based on the phylogenetic relationship and structure, (iii) secondary structures of the RNA component and tertiary structures of various subunits of telomerase, (iv) mutations of telomerase components found in human patients and (v) active researchers who contributed to the wealth of current knowledge on telomerase. The information is hierarchically organized by the components, i.e. the telomerase reverse transcriptase (TERT), telomerase RNA (TR) and other telomerase-associated proteins. The Telomerase Database is a useful resource especially for researchers who are interested in investigating the structure, function, evolution and medical relevance of the telomerase enzyme.


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