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Nucleic Acids Research Advance Access originally published online on October 4, 2007
Nucleic Acids Research 2008 36(Database issue):D372-D376; doi:10.1093/nar/gkm787
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Nucleic Acids Research, 2008, Vol. 36, Database issue D372-D376
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

Greglist: a database listing potential G-quadruplex regulated genes

Ren Zhang1, Yan Lin2 and Chun-Ting Zhang2,*

1Department of Epidemiology and Biostatistics, Tianjin Cancer Institute and Hospital, Tianjin 300060, China and 2Department of Physics, Tianjin University, Tianjin 300072, China

*To whom correspondence should be addressed. Tel: +86 22 27402987; Fax: +86 22 2335 8329; Email: ctzhang{at}tju.edu.cn

Received August 13, 2007. Revised September 15, 2007. Accepted September 17, 2007.

The double helix is a conformation that genomic DNA usually assumes; under certain conditions, however, guanine-rich DNA sequences can form a four-stranded structure, G-quadruplex, which is found to play a role in regulating gene expression. Indeed, it has been demonstrated that the G-quadruplex formed in the c-MYC promoter suppresses its transcriptional activity. Recent studies suggest that G-quadruplex motifs (GQMs) are enriched in human gene promoters. To facilitate the research of G-quadruplex, we have constructed Greglist, a database listing potentially G-quadruplex regulated genes. Greglist harbors genes that contain promoter GQMs from genomes of various species, including humans, mice, rats and chickens. Many important genes are found to contain previously unreported promoter GQMs, such as ATM, BAD, AKT1, LEPR, UCP1, APOE, DKK1, WT1, WEE1, WNT1 and CLOCK. Furthermore, we find that not only protein coding genes, 126 human microRNAs also contain promoter GQMs. Greglist therefore provides candidates for further studying G-quadruplex functions and is freely available at http://tubic.tju.edu.cn/greglist.


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