Skip Navigation


Nucleic Acids Research Advance Access originally published online on October 4, 2007
Nucleic Acids Research 2008 36(Database issue):D372-D376; doi:10.1093/nar/gkm787
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (83K) Freely available
Right arrow Screen PDF (93K) Freely available
Right arrow Supplementary Data
Right arrowOA All Versions of this Article:
36/suppl_1/D372    most recent
gkm787v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Zhang, R.
Right arrow Articles by Zhang, C.-T.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, R.
Right arrow Articles by Zhang, C.-T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 2008, Vol. 36, Database issue D372-D376
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Articles

Greglist: a database listing potential G-quadruplex regulated genes

Ren Zhang1, Yan Lin2 and Chun-Ting Zhang2,*

1Department of Epidemiology and Biostatistics, Tianjin Cancer Institute and Hospital, Tianjin 300060, China and 2Department of Physics, Tianjin University, Tianjin 300072, China

*To whom correspondence should be addressed. Tel: +86 22 27402987; Fax: +86 22 2335 8329; Email: ctzhang{at}tju.edu.cn

Received August 13, 2007. Revised September 15, 2007. Accepted September 17, 2007.

The double helix is a conformation that genomic DNA usually assumes; under certain conditions, however, guanine-rich DNA sequences can form a four-stranded structure, G-quadruplex, which is found to play a role in regulating gene expression. Indeed, it has been demonstrated that the G-quadruplex formed in the c-MYC promoter suppresses its transcriptional activity. Recent studies suggest that G-quadruplex motifs (GQMs) are enriched in human gene promoters. To facilitate the research of G-quadruplex, we have constructed Greglist, a database listing potentially G-quadruplex regulated genes. Greglist harbors genes that contain promoter GQMs from genomes of various species, including humans, mice, rats and chickens. Many important genes are found to contain previously unreported promoter GQMs, such as ATM, BAD, AKT1, LEPR, UCP1, APOE, DKK1, WT1, WEE1, WNT1 and CLOCK. Furthermore, we find that not only protein coding genes, 126 human microRNAs also contain promoter GQMs. Greglist therefore provides candidates for further studying G-quadruplex functions and is freely available at http://tubic.tju.edu.cn/greglist.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.