Skip Navigation


Nucleic Acids Research Advance Access originally published online on October 26, 2007
Nucleic Acids Research 2008 36(Database issue):D497-D503; doi:10.1093/nar/gkm905
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (11455K) Freely available
Right arrow Screen PDF (1323K) Freely available
Right arrow Supplementary Data
Right arrowOA All Versions of this Article:
36/suppl_1/D497    most recent
gkm905v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Squires, B.
Right arrow Articles by Scheuermann, R. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Squires, B.
Right arrow Articles by Scheuermann, R. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 2008, Vol. 36, Database issue D497-D503
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

BioHealthBase: informatics support in the elucidation of influenza virus host–pathogen interactions and virulence

Burke Squires1, Catherine Macken2, Adolfo Garcia-Sastre3, Shubhada Godbole1, Jyothi Noronha1, Victoria Hunt1, Roger Chang1, Christopher N. Larsen4, Ed Klem5, Kevin Biersack5 and Richard H. Scheuermann1,*

1University of Texas Southwestern Medical Center, Dallas, TX, 2Los Alamos National Laboratory, Los Alamos, NM, 3Mt Sinai School of Medicine, New York, NY, 4Vecna Technologies, College Park, MD and 5Northrop Grumman IT, Rockville, MD, USA

*To whom correspondence should be addressed. Tel: +1 214 648 4115; Fax: +1 214 648 4070; Email: richard.scheuermann{at}utsouthwestern.edu

Received August 15, 2007. Revised October 5, 2007. Accepted October 6, 2007.

The BioHealthBase Bioinformatics Resource Center (BRC) (http://www.biohealthbase.org) is a public bioinformatics database and analysis resource for the study of specific biodefense and public health pathogens—Influenza virus, Francisella tularensis, Mycobacterium tuberculosis, Microsporidia species and ricin toxin. The BioHealthBase serves as an extensive integrated repository of data imported from public databases, data derived from various computational algorithms and information curated from the scientific literature. The goal of the BioHealthBase is to facilitate the development of therapeutics, diagnostics and vaccines by integrating all available data in the context of host–pathogen interactions, thus allowing researchers to understand the root causes of virulence and pathogenicity. Genome and protein annotations can be viewed either as formatted text or graphically through a genome browser. 3D visualization capabilities allow researchers to view proteins with key structural and functional features highlighted. Influenza virus host–pathogen interactions at the molecular/cellular and systemic levels are represented. Host immune response to influenza infection is conveyed through the display of experimentally determined antibody and T-cell epitopes curated from the scientific literature or as derived from computational predictions. At the molecular/cellular level, the BioHealthBase BRC has developed biological pathway representations relevant to influenza virus host–pathogen interaction in collaboration with the Reactome database (http://www.reactome.org).


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
T. B. K. Reddy, R. Riley, F. Wymore, P. Montgomery, D. DeCaprio, R. Engels, M. Gellesch, J. Hubble, D. Jen, H. Jin, et al.
TB database: an integrated platform for tuberculosis research
Nucleic Acids Res., October 3, 2008; (2008) gkn652v1.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.