Nucleic Acids Research Advance Access originally published online on October 2, 2007
Nucleic Acids Research 2008 36(Database issue):D656-D661; doi:10.1093/nar/gkm761
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Nucleic Acids Research, 2008, Vol. 36, Database issue D656-D661
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]
Articles |
DOMINE: a database of protein domain interactions
1Department of Computer Science, University of Texas at Dallas, Richardson, TX 75083, USA, 210401 Grosvenor Pl, Rockville Pike, MD 20852, USA and 3National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
*To whom correspondence should be addressed. Tel: +1 301 402 8221; Fax: +1 301 480 4637; Email: jothi{at}mail.nih.gov
Received August 1, 2007. Revised August 27, 2007. Accepted September 11, 2007.
DOMINE is a database of known and predicted protein domain interactions compiled from a variety of sources. The database contains domain–domain interactions observed in PDB entries, and those that were predicted by eight different computational approaches. DOMINE contains a total of 20 513 unique domain–domain interactions among 4036 Pfam domains, out of which 4349 are inferred from PDB entries and 17 781 were predicted by at least one computational approach. This database will serve as a valuable resource to those working in the field of protein and domain interactions. DOMINE may not only serve as a reference to experimentalists who test for new protein and domain interactions, but also offers a consolidated dataset for analysis by bioinformaticians who seek to test ideas regarding the underlying factors that control the topological structure of interaction networks. DOMINE is freely available at http://domine.utdallas.edu.
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