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Nucleic Acids Research Advance Access originally published online on September 21, 2007
Nucleic Acids Research 2008 36(Database issue):D836-D841; doi:10.1093/nar/gkm730
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Nucleic Acids Research, 2008, Vol. 36, Database issue D836-D841
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

MethyCancer: the database of human DNA methylation and cancer

Ximiao He1,2, Suhua Chang1, Jiajie Zhang1,2, Qian Zhao1,2, Haizhen Xiang1, Kanthida Kusonmano1,3, Liu Yang4,5, Zhong Sheng Sun4, Huanming Yang1 and Jing Wang1,*

1Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101300, China, 2Graduate University of the Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100039, China, 3Bioinformatics Program, School of Bioresources and Technology and School of Information Technology, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand, 4Behavioral Genetics Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 101300, China and 5James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310007, China

*To whom correspondence should be addressed. Tel: +86 10 80485492; Fax: +86 10 80498676; Email: wangjing{at}genomics.org.cn

Received August 15, 2007. Accepted September 3, 2007.

Cancer is ranked as one of the top killers in all human diseases and continues to have a devastating effect on the population around the globe. Current research efforts are aiming to accelerate our understanding of the molecular basis of cancer and develop effective means for cancer diagnostics, treatment and prognosis. An altered pattern of epigenetic modifications, most importantly DNA methylation events, plays a critical role in tumorigenesis through regulating oncogene activation, tumor suppressor gene silencing and chromosomal instability. To study interplay of DNA methylation, gene expression and cancer, we developed a publicly accessible database for human DNA Methylation and Cancer (MethyCancer, http://methycancer.genomics.org.cn). MethyCancer hosts both highly integrated data of DNA methylation, cancer-related gene, mutation and cancer information from public resources, and the CpG Island (CGI) clones derived from our large-scale sequencing. Interconnections between different data types were analyzed and presented. Furthermore, a powerful search tool is developed to provide user-friendly access to all the data and data connections. A graphical MethyView shows DNA methylation in context of genomics and genetics data facilitating the research in cancer to understand genetic and epigenetic mechanisms that make dramatic changes in gene expression of tumor cells.

The authors wish it to be known that, in their opinion, the first four authors should be regarded as joint First Authors.


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