Skip Navigation


Nucleic Acids Research Advance Access originally published online on April 28, 2008
Nucleic Acids Research 2008 36(Web Server issue):W145-W148; doi:10.1093/nar/gkn228
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (3159K) Freely available
Right arrow Screen PDF (452K) Freely available
Right arrowOA All Versions of this Article:
36/suppl_2/W145    most recent
gkn228v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Grissa, I.
Right arrow Articles by Pourcel, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grissa, I.
Right arrow Articles by Pourcel, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 2008, Vol. 36, No. suppl_2 W145-W148
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Articles

CRISPRcompar: a website to compare clustered regularly interspaced short palindromic repeats

Ibtissem Grissa1,*, Gilles Vergnaud1,2 and Christine Pourcel1

1Univ. Paris-Sud 11, CNRS, UMR8621, Institut de Génétique et Microbiologie, 91405 Orsay and 2DGA/D4S - Mission pour la Recherche et l’Innovation Scientifique, 7, rue des Mathurins, 00470 Armées, France

*To whom correspondence should be addressed. Tel: +33 1 69 15 30 01; Fax: +33 1 69 15 66 78; Email: ibtissem.grissa{at}igmors.u-psud.fr

Received January 25, 2008. Revised April 6, 2008. Accepted April 11, 2008.

Clustered regularly interspaced short palindromic repeat (CRISPR) elements are a particular family of tandem repeats present in prokaryotic genomes, in almost all archaea and in about half of bacteria, and which participate in a mechanism of acquired resistance against phages. They consist in a succession of direct repeats (DR) of 24–47 bp separated by similar sized unique sequences (spacers). In the large majority of cases, the direct repeats are highly conserved, while the number and nature of the spacers are often quite diverse, even among strains of a same species. Furthermore, the acquisition of new units (DR + spacer) was shown to happen almost exclusively on one side of the locus. Therefore, the CRISPR presents an interesting genetic marker for comparative and evolutionary analysis of closely related bacterial strains. CRISPRcompar is a web service created to assist biologists in the CRISPR typing process. Two tools facilitates the in silico investigation: CRISPRcomparison and CRISPRtionary. This website is freely accessible at http://crispr.u-psud.fr/CRISPRcompar/.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.