Skip Navigation


Nucleic Acids Research Advance Access originally published online on July 22, 2009
Nucleic Acids Research 2009 37(17):5917-5929; doi:10.1093/nar/gkp608
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (9348K) Freely available
Right arrow Screen PDF (819K) Freely available
Right arrow Supplementary Data
Right arrowOA All Versions of this Article:
37/17/5917    most recent
gkp608v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Lavery, R.
Right arrow Articles by Zakrzewska, K.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lavery, R.
Right arrow Articles by Zakrzewska, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 2009, Vol. 37, No. 17 5917-5929
© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Structural Biology

Conformational analysis of nucleic acids revisited: Curves+

R. Lavery1,*, M. Moakher2, J. H. Maddocks3, D. Petkeviciute3 and K. Zakrzewska1,*

1Institut de Biologie et Chimie des Protéines, CNRS UMR 5086/Université de Lyon, 7 Passage du Vercors, 69367 Lyon, France, 2Laboratoire de Modélisation Mathématique et Numérique dans les Sciences de l'Ingénieur, Ecole Nationale d'Ingénieurs de Tunis, B.P. 37, 1002 Tunis-Belvédère, Tunisia and 3Institut de Mathématiques B, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland

*To whom correspondence should be addressed. Tel: +33 4 72 72 26 37; Fax: +33 4 72 72 26 04; Email: richard.lavery{at}ibcp.fr Correspondence may also be addressed to K. Zakrzewska. Tel: +33 4 72 72 26 37; Fax: +33 4 72 72 26 04; Email: krystyna.zakrzewska{at}ibcp.fr

Received April 22, 2009. Revised July 5, 2009. Accepted July 6, 2009.

We describe Curves+, a new nucleic acid conformational analysis program which is applicable to a wide range of nucleic acid structures, including those with up to four strands and with either canonical or modified bases and backbones. The program is algorithmically simpler and computationally much faster than the earlier Curves approach, although it still provides both helical and backbone parameters, including a curvilinear axis and parameters relating the position of the bases to this axis. It additionally provides a full analysis of groove widths and depths. Curves+ can also be used to analyse molecular dynamics trajectories. With the help of the accompanying program Canal, it is possible to produce a variety of graphical output including parameter variations along a given structure and time series or histograms of parameter variations during dynamics.

The authors wish it to be known that, in their opinion, the first and the last authors should be regarded as joint First Authors.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
F. Lankas, N. Spackova, M. Moakher, P. Enkhbayar, and J. Sponer
A measure of bending in nucleic acids structures applied to A-tract DNA
Nucleic Acids Res., January 31, 2010; (2010): gkq001v1 - gkq001.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.