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Nucleic Acids Research Advance Access originally published online on August 19, 2009
Nucleic Acids Research 2009 37(18):6239-6248; doi:10.1093/nar/gkp630
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Nucleic Acids Research, 2009, Vol. 37, No. 18 6239-6248
© The Author 2009. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses?by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Structural Biology

Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad

Kah Wai Lim1, Patrizia Alberti2, Aurore Guédin2, Laurent Lacroix2, Jean-François Riou2, Nicola J. Royle3, Jean-Louis Mergny2,* and Anh Tuân Phan1,*

1Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 2INSERM U565, CNRS UMR 7196, USM 503, Muséum National d’Histoire Naturelle, Paris, France and 3Department of Genetics, University of Leicester, Leicester, LE1 7RH, UK

*To whom correspondence should be addressed. Tel: +65 6514 1915; Fax: +65 6795 7981; Email: phantuan{at}ntu.edu.sg

Correspondence may also be addressed to Jean-Louis Mergny. Email: mergny{at}mnhn.fr

Received May 12, 2009. Revised July 14, 2009. Accepted July 14, 2009.

Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four human telomeric variant CTAGGG repeats in potassium solution. Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G·C base pair and a G·C·G·C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA.

Present address: IECB, INSERM U869, Pessac, France.


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A. Mendez-Bermudez, M. Hills, H. A. Pickett, A. T. Phan, J.-L. Mergny, J.-F. Riou, and N. J. Royle
Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germline
Nucleic Acids Res., October 1, 2009; 37(18): 6225 - 6238.
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