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Nucleic Acids Research Advance Access originally published online on October 28, 2008
Nucleic Acids Research 2009 37(Database issue):D159-D162; doi:10.1093/nar/gkn772
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Nucleic Acids Research, 2009, Vol. 37, Database issue D159-D162
Published by Oxford University Press 2008
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

tRNAdb 2009: compilation of tRNA sequences and tRNA genes

Frank Jühling1, Mario Mörl2, Roland K. Hartmann3, Mathias Sprinzl4, Peter F. Stadler1,5,6,7 and Joern Pütz8,*

1Bioinformatics Group, Department of Computer Science and Interdisciplinary Center for Bioinformatics, University of Leipzig, Härtelstrasse 16-18, D-04107 Leipzig, 2Institute for Biochemistry, University of Leipzig, Brüderstrasse 34, 04103 Leipzig, 3Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, D-35037 Marburg, 4Laboratorium für Biochemie, Universität Bayreuth, Universitätsstrasse 30, D-95440 Bayreuth, 5RNomics Group, Fraunhofer Institut für Zelltherapie und Immunologie, Perlickstrasse 1, D-04103 Leipzig, Germany, 6Department of Theoretical Chemistry, University of Vienna, Währingerstrasse 17, A-1090 Wien, Austria, 7Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe, NM 87501, USA and 8Architecture et Réactivité de l'ARN, Université Louis Pasteur de Strasbourg, CNRS, IBMC, 15 rue René Descartes, 67084 Strasbourg, France

*To whom correspondence should be addressed. Tel: +33 3 88 41 70 48; Fax: +33 3 88 60 22 18; Email: j.puetz{at}ibmc.u-strasbg.fr

Received September 11, 2008. Accepted October 7, 2008.

One of the first specialized collections of nucleic acid sequences in life sciences was the ‘compilation of tRNA sequences and sequences of tRNA genes’ (http://www.trna.uni-bayreuth.de). Here, an updated and completely restructured version of this compilation is presented (http://trnadb.bioinf.uni-leipzig.de). The new database, tRNAdb, is hosted and maintained in cooperation between the universities of Leipzig, Marburg, and Strasbourg. Reimplemented as a relational database, tRNAdb will be updated periodically and is searchable in a highly flexible and user-friendly way. Currently, it contains more than 12 000 tRNA genes, classified into families according to amino acid specificity. Furthermore, the implementation of the NCBI taxonomy tree facilitates phylogeny-related queries. The database provides various services including graphical representations of tRNA secondary structures, a customizable output of aligned or un-aligned sequences with a variety of individual and combinable search criteria, as well as the construction of consensus sequences for any selected set of tRNAs.


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