Nucleic Acids Research Advance Access originally published online on October 15, 2008
Nucleic Acids Research 2009 37(Database issue):D417-D422; doi:10.1093/nar/gkn708
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Nucleic Acids Research, 2009, Vol. 37, Database issue D417-D422
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]
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Human immunodeficiency virus type 1, human protein interaction database at NCBI
1Southern Research Institute, Frederick, MD 21701 and 2National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA
*To whom correspondence should be addressed. Tel: +1 301 694 3232, ext.217; Fax: +1 301 694 7223; Email: fu{at}southernresearch.org
Received August 29, 2008. Revised September 26, 2008. Accepted September 29, 2008.
The ‘Human Immunodeficiency Virus Type 1 (HIV-1), Human Protein Interaction Database’, available through the National Library of Medicine at www.ncbi.nlm.nih.gov/RefSeq/HIVInteractions, was created to catalog all interactions between HIV-1 and human proteins published in the peer-reviewed literature. The database serves the scientific community exploring the discovery of novel HIV vaccine candidates and therapeutic targets. To facilitate this discovery approach, the following information for each HIV-1 human protein interaction is provided and can be retrieved without restriction by web-based downloads and ftp protocols: Reference Sequence (RefSeq) protein accession numbers, Entrez Gene identification numbers, brief descriptions of the interactions, searchable keywords for interactions and PubMed identification numbers (PMIDs) of journal articles describing the interactions. Currently, 2589 unique HIV-1 to human protein interactions and 5135 brief descriptions of the interactions, with a total of 14 312 PMID references to the original articles reporting the interactions, are stored in this growing database. In addition, all protein–protein interactions documented in the database are integrated into Entrez Gene records and listed in the ‘HIV-1 protein interactions’ section of Entrez Gene reports. The database is also tightly linked to other databases through Entrez Gene, enabling users to search for an abundance of information related to HIV pathogenesis and replication.
Present address: Brigitte E. Sanders-Beer, BIOQUAL, Inc., Rockville, MD 20850 USA
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