Nucleic Acids Research Advance Access originally published online on October 3, 2008
Nucleic Acids Research 2009 37(Database issue):D499-D508; doi:10.1093/nar/gkn652
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Nucleic Acids Research, 2009, Vol. 37, Database issue D499-D508
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]
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TB database: an integrated platform for tuberculosis research
1Department of Biochemistry, Stanford University, CA 94305, 2Broad Institute of MIT and Harvard, Cambridge, MA 02142, 3Department of Genetics, Stanford University, CA 94305, 4Department of Biomedical Engineering, Boston University, Boston, MA 02215, 5National Emerging Infectious Diseases Lab, Boston University, Boston MA 02118 and 6Department of Microbiology & Immunology, Stanford University, CA 94305, USA
*To whom correspondence should be addressed. Tel: 650 736 0075; Fax: 650 724 3701; Email: tbreddy{at}stanford.edu
Received August 14, 2008. Revised September 17, 2008. Accepted September 18, 2008.
The effective control of tuberculosis (TB) has been thwarted by the need for prolonged, complex and potentially toxic drug regimens, by reliance on an inefficient vaccine and by the absence of biomarkers of clinical status. The promise of the genomics era for TB control is substantial, but has been hindered by the lack of a central repository that collects and integrates genomic and experimental data about this organism in a way that can be readily accessed and analyzed. The Tuberculosis Database (TBDB) is an integrated database providing access to TB genomic data and resources, relevant to the discovery and development of TB drugs, vaccines and biomarkers. The current release of TBDB houses genome sequence data and annotations for 28 different Mycobacterium tuberculosis strains and related bacteria. TBDB stores pre- and post-publication gene-expression data from M. tuberculosis and its close relatives. TBDB currently hosts data for nearly 1500 public tuberculosis microarrays and 260 arrays for Streptomyces. In addition, TBDB provides access to a suite of comparative genomics and microarray analysis software. By bringing together M. tuberculosis genome annotation and gene-expression data with a suite of analysis tools, TBDB (http://www.tbdb.org/) provides a unique discovery platform for TB research.
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