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Nucleic Acids Research Advance Access originally published online on November 4, 2008
Nucleic Acids Research 2009 37(Database issue):D647-D650; doi:10.1093/nar/gkn799
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Nucleic Acids Research, 2009, Vol. 37, Database issue D647-D650
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

PIG—the pathogen interaction gateway

Tim Driscoll1, Matthew D. Dyer1, T. M. Murali2 and Bruno W. Sobral1,*

1Virginia Bioinformatics Institute and 2Department of Computer Science, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA

*To whom correspondence should be addressed. Tel: +1 540 231 2582; Fax: +1 540 231 2606; Email: sobral{at}vt.edu

Correspondence may also be addressed to T. M. Murali. Tel: +1 540 231 8534; Fax: +1 540 231 6075; Email: murali{at}cs.vt.edu

Received August 15, 2008. Revised September 15, 2008. Accepted October 10, 2008.

Protein–protein interactions (PPIs) play a vital role in initiating infection in a number of pathogens. Identifying which interactions allow a pathogen to infect its host can help us to understand methods of pathogenesis and provide potential targets for therapeutics. Public resources for studying host–pathogen systems, in particular PPIs, are scarce. To facilitate the study of host–pathogen PPIs, we have collected and integrated host–pathogen PPI (HP–PPI) data from a number of public resources to create the Pathogen Interaction Gateway (PIG). PIG provides a text based search and a BLAST interface for searching the HP–PPI data. Each entry in PIG includes information such as the functional annotations and the domains present in the interacting proteins. PIG provides links to external databases to allow for easy navigation among the various websites. Additionally, PIG includes a tool for visualizing a single HP–PPI network or two HP–PPI networks. PIG can be accessed at http://pig.vbi.vt.edu.

Present address: Matthew D. Dyer, Department of Microbiology, University of Washington, Seattle, WA 98195, USA

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.


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