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Nucleic Acids Research Advance Access originally published online on October 23, 2008
Nucleic Acids Research 2009 37(Database issue):D797-D802; doi:10.1093/nar/gkn748
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Nucleic Acids Research, 2009, Vol. 37, Database issue D797-D802
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

HGVbaseG2P: a central genetic association database

Gudmundur A. Thorisson1, Owen Lancaster1, Robert C. Free1, Robert K. Hastings1, Pallavi Sarmah2, Debasis Dash2, Samir K. Brahmachari2 and Anthony J. Brookes1,*

1Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK and 2Institute of Genomics and Integrative Biology, CSIR, Delhi, India

*To whom correspondence should be addressed. Tel: +44 116 252 3401; Fax: +44 116 252 3378; Email: ajb97{at}leicester.ac.uk

Received September 14, 2008. Accepted October 3, 2008.

The Human Genome Variation database of Genotype to Phenotype information (HGVbaseG2P) is a new central database for summary-level findings produced by human genetic association studies, both large and small. Such a database is needed so that researchers have an easy way to access all the available association study data relevant to their genes, genome regions or diseases of interest. Such a depository will allow true positive signals to be more readily distinguished from false positives (type I error) that fail to consistently replicate. In this paper we describe how HGVbaseG2P has been constructed, and how its data are gathered and organized. We present a range of user-friendly but powerful website tools for searching, browsing and visualizing G2P study findings. HGVbaseG2P is available at http://www.hgvbaseg2p.org.


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