Nucleic Acids Research Advance Access originally published online on October 15, 2008
Nucleic Acids Research 2009 37(Database issue):D98-D104; doi:10.1093/nar/gkn714
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Nucleic Acids Research, 2009, Vol. 37, Database issue D98-D104
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]
Articles |
miR2Disease: a manually curated database for microRNA deregulation in human disease
1Center for Biomedical Informatics, School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China, 2Center for Computational Biology and Bioinformatics, 3Division of Biostatistics, Department of Medicine and 4Center for Medical Genomics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
*To whom correspondence should be addressed. Tel: +86 138 0450 5289; Fax: +1 317 278 9217; Email: ydwang{at}hit.edu.cn
Correspondence may also be addressed to Yunlong Liu. Tel: +1 317 278 9222; Fax: 1 317 278 9217; Email: yunliu{at}iupui.edu
Received July 15, 2008. Revised September 29, 2008. Accepted September 30, 2008.
‘miR2Disease’, a manually curated database, aims at providing a comprehensive resource of microRNA deregulation in various human diseases. The current version of miR2Disease documents 1939 curated relationships between 299 human microRNAs and 94 human diseases by reviewing more than 600 published papers. Around one-seventh of the microRNA–disease relationships represent the pathogenic roles of deregulated microRNA in human disease. Each entry in the miR2Disease contains detailed information on a microRNA–disease relationship, including a microRNA ID, the disease name, a brief description of the microRNA–disease relationship, an expression pattern of the microRNA, the detection method for microRNA expression, experimentally verified target gene(s) of the microRNA and a literature reference. miR2Disease provides a user-friendly interface for a convenient retrieval of each entry by microRNA ID, disease name, or target gene. In addition, miR2Disease offers a submission page that allows researchers to submit established microRNA–disease relationships that are not documented. Once approved by the submission review committee, the submitted records will be included in the database. miR2Disease is freely available at http://www.miR2Disease.org.
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