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Nucleic Acids Research Advance Access originally published online on May 19, 2009
Nucleic Acids Research 2009 37(Web Server issue):W109-W114; doi:10.1093/nar/gkp402
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Nucleic Acids Research, 2009, Vol. 37, No. suppl_2 W109-W114
© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Articles

SNOW, a web-based tool for the statistical analysis of protein–protein interaction networks

Pablo Minguez1, Stefan Götz1,2, David Montaner1, Fatima Al-Shahrour1 and Joaquin Dopazo1,2,3,*

1Department of Bioinformatics and Genomics, Centro de Investigación Príncipe Felipe (CIPF), 2CIBER de Enfermedades Raras (CIBERER) and 3Functional Genomics Node (INB) at CIPF, Valencia, Spain

*To whom correspondence should be addressed. Tel: +34 963289680; Fax: +34 963289701; Email: jdopazo{at}cipf.es

Received January 21, 2009. Revised April 22, 2009. Accepted May 2, 2009.

Understanding the structure and the dynamics of the complex intercellular network of interactions that contributes to the structure and function of a living cell is one of the main challenges of today's biology. SNOW inputs a collection of protein (or gene) identifiers and, by using the interactome as scaffold, draws the connections among them, calculates several relevant network parameters and, as a novelty among the rest of tools of its class, it estimates their statistical significance. The parameters calculated for each node are: connectivity, betweenness and clustering coefficient. It also calculates the number of components, number of bicomponents and articulation points. An interactive network viewer is also available to explore the resulting network. SNOW is available at http://snow.bioinfo.cipf.es.


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