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Nucleic Acids Research Advance Access originally published online on June 2, 2009
Nucleic Acids Research 2009 37(Web Server issue):W345-W349; doi:10.1093/nar/gkp463
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Nucleic Acids Research, 2009, Vol. 37, No. suppl_2 W345-W349
© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Articles

G-SESAME: web tools for GO-term-based gene similarity analysis and knowledge discovery

Zhidian Du1, Lin Li1, Chin-Fu Chen2, Philip S. Yu3 and James Z. Wang1,*

1School of Computing, 2Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634 and 3Department of Computer Science, University of Illinois at Chicago, 851 S. Morgan St., Rm 1138 SEO, Chicago, IL 60607, USA

*To whom correspondence should be addressed. Tel: +1 864 506 0283; Fax: +1 858 658 2100; Email: jzwang{at}cs.clemson.edu

Received February 21, 2009. Revised April 28, 2009. Accepted May 16, 2009.

We have developed a set of online tools for measuring the semantic similarities of Gene Ontology (GO) terms and the functional similarities of gene products, and for further discovering biomedical knowledge from the GO database. The tools have been used for about 6.9 million times by 417 institutions from 43 countries since October 2006. The online tools are available at: http://bioinformatics.clemson.edu/G-SESAME.


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