Nucleic Acids Research Advance Access originally published online on May 8, 2009
Nucleic Acids Research 2009 37(Web Server issue):W510-W514; doi:10.1093/nar/gkp322
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Nucleic Acids Research, 2009, Vol. 37, No. suppl_2 W510-W514
© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Articles |
QMEAN server for protein model quality estimation
1Biozentrum, University of Basel, Switzerland and 2SIB Swiss Institute of Bioinformatics, Basel, Switzerland
*To whom correspondence should be addressed. Tel: +41 61 267 15 81; Fax: +41 61 267 15 84; Email: torsten.schwede{at}unibas.ch
Received January 30, 2009. Revised April 15, 2009. Accepted April 20, 2009.
Model quality estimation is an essential component of protein structure prediction, since ultimately the accuracy of a model determines its usefulness for specific applications. Usually, in the course of protein structure prediction a set of alternative models is produced, from which subsequently the most accurate model has to be selected. The QMEAN server provides access to two scoring functions successfully tested at the eighth round of the community-wide blind test experiment CASP. The user can choose between the composite scoring function QMEAN, which derives a quality estimate on the basis of the geometrical analysis of single models, and the clustering-based scoring function QMEANclust which calculates a global and local quality estimate based on a weighted all-against-all comparison of the models from the ensemble provided by the user. The web server performs a ranking of the input models and highlights potentially problematic regions for each model. The QMEAN server is available at http://swissmodel.expasy.org/qmean.