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Nucleic Acids Research, 1977, Vol. 4, No. 1 141-148
© 1977

Articles

Levels of DNA polymerase -{alpha} and ß in normal and xeroderma pigmentosum fibroblasts

Umberto Bertazzonl, Miria Stefanini, Guido Pedrali-Noy, Fiorella Nuzzo and Arturo Falaschi

Laboratorio di Genetica Biochimica ed Evohizionistica del Consiglio Nazionale delle Ricerche Via S.Epifanio, 14-27100 Pavia, Italy

Received October 8, 1976. We have determined the levels of DNA-polymerases -{alpha} and - ß in fibroblasts obtainedfrom normal subjects and from patients with Xeroderma Pigmentosum (XP) belonging to three different complementation groups and to the variant form. The assays have been performed in crude extracts and after fractionation on sucrose gradients. The levels of {alpha} and ß-polymerases in the different casesof XP were found to lie within the same range as the control values, and no correlation was found with the severity of the symptoms. The sedimentation coefficients of the two polymerases from all the pathological lines were identical to those of the normal fibroblasts.


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