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Nucleic Acids Research, 1977, Vol. 4, No. 10 3357-3369
© 1977

Articles

5' Caps in hnRNA: absence of m32, 2, 7G and size distribution of capped molecules

R. Fernandez-Munoz, U. Lavi and J. E. Darnell

The Rockefeller University New York, NY 10021, USA

Received August 2, 1977. In HeLa cells the "small nuclear" RNA has a cap II 5' structure (8) — m32, 2, 7G(5') pppXmpYmp — where X and Y are 2'0 methylated adenosine and uridine. In contrast hnRNA contains only cap I structures where the 2'0 methylated residue may be any base as was earlier reported for cytoplasmic mRNA (8, 9, 11).

With a clear distinction between the source of these two caps an analysis of the size distribution of capped hnRNA could be performed which revealed over 65% of the capped hnRNA molecules were larger than cytoplasmic mRNA.


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