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Nucleic Acids Research, 1977, Vol. 4, No. 10 3473-3482
© 1977

Articles

Metabolic heterogeneity of nuclear poly (A)-containing RNA in mouse liver

T. V. Chemovskaya and M. I. Lerman

Institute of Biological and Medical Chemistry, Academy of Medical Sciences of the USSR Moscow, USSR

Received June 21, 1977. The analysis by the approach to equilibrium labeling method has shown that the poly(A)+ fraction of liver hnRNA is not a uniform class of molecules, but is comprised of two distinct subclasses with half-lives of 5 and 60 min, while the poly(A)– hnRNA was metabolically homogeneous and turned over with a rather uniform half-life of 30 min. The results suggest that (a) poly(A) synthesis and addition is not limiting for the rate of hnRNA processing, and (b) there is a correlation between the kinetics of mRNA appearance in the cytoplasm and kinetic behaviour of their possible nuclear precursors.


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