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Nucleic Acids Research, 1977, Vol. 4, No. 10 3643-3653
© 1977

Articles

Biologic activities of poly (2-azaadenylic acid) and poly (2-azainosinic acid)

Erik de Clercq, Guang-Fu Huang, Faculty of Pharmaceutical Sciences*, Paul F. Torrence*, Toshikazu Fukui+, Nobuko Kakiuchi, Faculty of Pharmaceutical Sciences+ and Morio Ikehara, Faculty of Pharmaceutical Sciences+

Rega Institute for Medical Research, University of Leuven Minderbroedersstraat 10, B-3000 Leuven, Belgium

Received August 17, 1977.

Poly(2-azaadenylic acid) ((aza2A)n) and poly(2-azainosinic acid ((aza2l)n), two newly synthesized analogues of (A)n and (I)n, in which CH-2 of the purine ring is replaced by a nitrogen atom, have been evaluated in various biological assay systems. (Aza2A)n formed a complex with (U)n and (br5U)n, and (aza2l)n formed a complex with (C)n and (br5C)n, but these complexes were markedly destabilized relative to the corresponding (A)n or (I)n complexes. The (aza2A)n- and (aza2l)n-derived complexes failed to stimulate the production of interferon in primary rabbit kidney cells and human diploid fibroblasts, under conditions (A)n.(U)n, (I)n.(C)n and (I)n. (br5C)n induced high amounts of interferon. Both (aza2A)n and (aza2l)n exerted a marked inhibitory effect on the endogenous RNA directed DNA poly-merase (reverse transcriptase) activity associated with murine leukemia virus. They caused a relatively mild inhibition of complement activity in an hemolytic assay system.

* Laboratory of Chemistry, National Institute of Arthritis and Metabolism and Digestive Diseases, National Institutes of Health Bethesda, Maryland 20014, USA.

+Osaka University 133–1 Yamada-Kami, Suita, Osaka 565, Japan.


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