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Nucleic Acids Research, 1977, Vol. 4, No. 11 3753-3768
© 1977

Articles

Intramolecular base composition heterogeneity of human DNA

Douglas L. Vizard{dagger},{dagger}, Frank P. Rinehart*, Carol M. Rubin** and Carl W. Schmid**

{dagger}Dep. Phys., Univ. Texas System Cancer Cent., M.D. Anderson Hosp. and Tumour Inst. 6723 Bertner Ave., Houston, TX 77030 *Div, Sci.and Math., Coll. of the Virgin Islands St. Thomas, VI 00801 **Dep. Chem., Univ. California, Davis, CA 95616, USA

{dagger}To whom reprint request should be addressed

Received July 22, 1977. The intramolecular base composition heterogeneity of human DNA has been investigated by electron microscopic observations of partially denatured structures and by equilibrium solution thermal denaturation techniques. DNA sequences having an average length of less than 2000 base pairs are found to be heterogeneous in base composition. These heterogeneous sequences occupy a minimum of 67 to 81% of the human genome.


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